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After binding to a ligand metabolite or a protein, the dissociation of Zn 2+ to form the hydrated cation occurs far more slowly than for Ca 2+ , for example (dissociation rate constant k off is around five orders of magnitude smaller, based on approximated generalized rate constants) (Fraústo da Silva & Williams, Reference Fraústo da Silva and Williams2001)
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An historical example is British antilewisite (BAL), developed during the Second World War, which was used to counteract arsenic-based war agents and other heavy metal toxicities